Publications


Title : Go-and-Back method: Effective estimation of the hidden motion of proteins from single-molecule time series

Language: English
Type: Article
Authors: Makito Miyazaki and Takahiro Harada
Journal: Journal of Chemical Physics
ISSN: 0021-9606
Volume: 134
Number: 13
Month: 4
Year: 2011
Actual year: 2011
Pages: 32767-9
URL:   http://link.aip.org/link/doi/10.1063/1.3574396
doi:   10.1063/1.3574396
Abstract: We present an effective method for estimating the motion of proteins from the motion of attached probe particles in single-molecule experiments. The framework naturally incorporates Langevin dynamics to compute the most probable trajectory of the protein. By using a perturbation expansion technique, we achieve computational costs more than 3 orders of magnitude smaller than the conventional gradient descent method without loss of simplicity in the computation algorithm. We present illustrative applications of the method using simple models of single-molecule experiments and confirm that the proposed method yields reasonable and stable estimates of the hidden motion in a highly efficient manner.

"Go-and-Back method: Effective estimation of the hidden motion of proteins from single-molecule time series"

Makito Miyazaki and Takahiro Harada, Journal of Chemical Physics, 134, 32767-9 (2011)