Title : Lamellar-lamellar phase separation of phospholipid bilayers induced by salting-in/-out effects

Language: English
Type: Article
Authors: Mafumi Hishida and Hideki Seto
Journal: Journal of Physics: Conference Series
Volume: 272
Number: 1
Month: 3
Year: 2011
Actual year: 2009
Pages: 12008-6
doi:   10.1088/1742-6596/272/1/012008
Abstract: The multilamellar structure of phospholipid bilayers is stabilized by the interactions between bilayers. Although the lamellar repeat distance is uniquely determined at the balance point of interactions between bilayers, a lamellar-lamellar phase separation, where the two phases with different lamellar repeat distance coexist, has been reported in a case of adding a salt to the aqueous solution of lipids. In order to understand the physical mechanism of the lamellar-lamellar phase separation, the effects of adding monovalent salt on the lamellar structure are studied by visual observation and by small-angle X-ray scattering. Further, a theoretical model based on the mean field theory is introduced and it is concluded that the salting-in and -out effects of lipid bilayers trigger the lamellar-lamellar phase separation.

"Lamellar-lamellar phase separation of phospholipid bilayers induced by salting-in/-out effects"

Mafumi Hishida and Hideki Seto, Journal of Physics: Conference Series, 272, 12008-6 (2011)