| Language: | English |
|---|---|
| Type: | Article |
| Authors: | Makito Miyazaki and Takahiro Harada |
| Journal: | Journal of Chemical Physics |
| ISSN: | 0021-9606 |
| Volume: | 134 |
| Number: | 13 |
| Month: | 4 |
| Year: | 2011 |
| Actual year: | 2011 |
| Pages: | 32767-9 |
| URL: | http://link.aip.org/link/doi/10.1063/1.3574396 |
| doi: | 10.1063/1.3574396 |
| Abstract: | We present an effective method for estimating the motion of proteins from the motion of attached probe particles in single-molecule experiments. The framework naturally incorporates Langevin dynamics to compute the most probable trajectory of the protein. By using a perturbation expansion technique, we achieve computational costs more than 3 orders of magnitude smaller than the conventional gradient descent method without loss of simplicity in the computation algorithm. We present illustrative applications of the method using simple models of single-molecule experiments and confirm that the proposed method yields reasonable and stable estimates of the hidden motion in a highly efficient manner. |
Makito Miyazaki and Takahiro Harada, Journal of Chemical Physics, 134, 32767-9 (2011)