Publications


Title : ATP/ADP switches the higher-order structure of DNA in the presence of spermidine

Language: English
Type: Article
Authors: Naoko Makita and Kenichi Yoshikawa
Journal: FEBS Letters
ISSN: 0014-5793
Volume: 460
Number: 2
Month: 10
Year: 1999
Actual year: 1999
Pages: 333-337
doi:   10.1016/s0014-5793(99)01368-x
Abstract: In the living cellular environment, DNAs exist in a compact state in the presence of a polyamine, such as spermidine, We found that the hydrolysis of.-ITP into ADP induces the folding of elongated DNAs, by the single-chain observation of individual T4 DNA molecules, This result is discussed in relation to the possible role of ATP as a regulatory factor in genetic activity, in addition to its well-established role as an energy source, (C) 1999 Federation of European Biochemical Societies.

"ATP/ADP switches the higher-order structure of DNA in the presence of spermidine"

Naoko Makita and Kenichi Yoshikawa, FEBS Letters, 460, 333-337 (1999)