Publications


Title : Histone Core Slips along DNA and Prefers Positioning at the Chain End

Language: English
Type: Article
Authors: Takahiro Sakaue, Kenichi Yoshikawa, Shige H. Yoshimura and Kunio Takeyasu
Journal: Physical Review Letters
ISSN: 0031-9007
Volume: 87
Number: 7
Month: 8
Year: 2001
Actual year: 2001
Pages: 32767-4
doi:   10.1103/physrevlett.87.078105
Abstract: We studied the stability and dynamics of a model of a nucleosome, the fundamental unit for the packing of long DNA in eukaryotes, using a Brownian dynamics simulation. For the proper folding of a stiff polymer on a core particle, moderate attractive interaction is shown to be essentially important, which explains the empirical experimental protocol for the reconstitution of nucleosomes. The effect of the chain end on the positioning of the core particle is examined and compared with the experimental data by atomic force microscopy measurement. It is also suggested that the core particle exhibits sliding motion alongthe chain as a manifestation of Brownian motion.

"Histone Core Slips along DNA and Prefers Positioning at the Chain End"

Takahiro Sakaue, Kenichi Yoshikawa, Shige H. Yoshimura and Kunio Takeyasu, Physical Review Letters, 87, 32767-4 (2001)