Publications
Title:
Comparative study of kinetics on DNA double-strand break induced by photo- and gamma-irradiation: Protective effect of water-soluble flavonoids
| Language: | English |
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| Type: | Article |
| Authors: | Yuko Yoshikawa, Toshiaki Mori, Mari Suzuki, Tadayuki Imanaka and Kenichi Yoshikawa |
| Editors: | |
| Journal: | Chemical Physics Letters |
| Volume: | 501 |
| Number: | 1-3 |
| Month: | 12 |
| Year: | 2010 |
| Actual year: | 2010 |
| Pages: | 146–151 |
| URL: | http://www.sciencedirect.com/science/article/pii/S000926141001448X |
| doi: | 10.1016/j.cplett.2010.11.003 |
| bibtex id: | 2010_CPL_Yuko_10-30 |
| Abstract: | The double-strand break of DNA induced by visible light and γ-rays was studied through a single-molecule observation using fluorescence microscopy. We evaluated the protective effects of water-soluble derivatives of flavonoids, α-glucosyl hesperidin (αG-HSP) and α-glucosyl rutin (αG-rutin) in a quantitative manner. With regard to photo-induced damage, αG-rutin was found to provide twice as much protection as αG-HSP, whereas the protective effect of αG-rutin against γ-ray irradiation was comparable with that of αG-HSP. This observation demonstrates the dependence of the antioxidant potentials of these compounds on the source of irradiation. |
| Acknowledgment: |
| 2010 | |
| "Comparative study of kinetics on DNA double-strand break induced by photo- and gamma-irradiation: Protective effect of water-soluble flavonoids" Yuko Yoshikawa, Toshiaki Mori, Mari Suzuki, Tadayuki Imanaka and Kenichi Yoshikawa, Chemical Physics Letters, 501(1-3), 146–151 (2010) | detail publisher doi:10.1016/j.cplett.2010.11.003 |
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