| Language: | English |
|---|---|
| Type: | Article |
| Authors: | Yoshiko Takenaka, Hiroki Nagahara, Hiroyuki Kitahata and Kenichi Yoshikawa |
| Journal: | Physical Review E |
| ISSN: | 1539-3755 |
| Volume: | 77 |
| Number: | 3 |
| Month: | 3 |
| Year: | 2008 |
| Actual year: | 2008 |
| Pages: | 31905-4 |
| URL: | http://link.aps.org/doi/10.1103/PhysRevE.77.031905 |
| doi: | 10.1103/physreve.77.031905 |
| Abstract: | We present a model to describe the on-off switching of transcriptional activity in a genetic assembly by considering the intrinsic characteristics of a giant genomic DNA molecule which can undergo a discrete structural transition between coiled and compact states. We propose a model in which the transition in the higher-order structure of DNA plays an essential role in regulating stable on-off switching and/or the oscillation of a large number of genes under the fluctuations in a living cell, where such a structural transition is caused by environmental factors. This model explains the rapid and broad transcriptional response in a genetic assembly as well as its robustness against fluctuations. |
Yoshiko Takenaka, Hiroki Nagahara, Hiroyuki Kitahata and Kenichi Yoshikawa, Physical Review E, 77, 31905-4 (2008)